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Obligatory Sakura
But otherwise, Frederica Greenhill. LotGH is a great anime (and Yang is one of my favourite fictional characters), but the entire series has just two memorable female characters - Hilda and Jessica. Frederica gets a lot of screen time, but 99% of the time she’s just there.
Detective series set in medieval China. A lot of thought has gone into writing the characters, as well as the medical / botanical side and the society and culture of that time. (Not saying it is 100% historically realistic; it sacrifices some accuracy for plot reasons.) Also a lot of comedy, mostly revolving around the main character Mao Mao (her name sounds like ‘Cat Cat’), who is extremely intelligent but also uncontrollably curious about poisons.