Lucky Star and K-on for CGDCT
Evangelion for meta-commentary and deconstruction, to the point that future works that qualify often get called the “Evangelion of <genre>”
Fullmetal Alchemist Brotherhood and Attack on Titan for battle shounen
Bocchi the Rock for girls band anime, specifically
Lupin III: The Castle of Cagliostro for pretty much all of Ghibli
Akira for 90s anime
I heard that Melancholy of Haruhi Suzumiya is “blueprint” for many modern animes (Bunny Girl Senpai and other where there is 1 guy with many girls around, but not harem).